Table 4 Candidate SNP markers of obesity-related aggressiveness (these markers may change the TBP–promoter affinity)
Gene | dbSNP [12] or see [Reference] | 5′ flank | \( \frac{\mathbf{wt}}{mut} \) | 3′ flank | KD, nM | Z-score | Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1) | [Ref] or [this work] | ||
|---|---|---|---|---|---|---|---|---|---|---|
\( \frac{\mathbf{wt}}{mut} \) | Δ | Z | α | |||||||
PGR | rs10895068 | gggagataaa | \( \frac{\mathbf{g}}{a} \) | gagccgcgtg | \( \frac{\mathbf{10}}{6} \) | ↑ | 8 | 10−6 | Endometrial cancer in obese women [de novo pathogenic TATA box], and also (hypothetically) obese school-aged girls show verbal aggressiveness (e.g., victimization); obese females are more aggressive (primate model); obesity and aggression coexist in polycystic ovary syndrome in women with biliary calculi (retrospective clinical reviews); high aggression/rejection in reproductive behavior (mice); low attraction and high aggression against males in females (rabbit model) | |
LEP | rs201381696 | tcgggccgct | \( \frac{\mathbf{a}}{g} \) | taagaggggc | \( \frac{\mathbf{4}}{12} \) | ↓ | 17 | 10−6 | (hypothetically) obesity and also, in a 10 yo girl, aggressiveness is a predictive factor for prevention of obesity in adolescence with cardiovascular complications in adulthood, as is the case for 5 yo boys (retrospective review); aberrant maternal behavior, low aggression against an unknown social stimulus and locomotor activity during a high-fat diet (mice); low chance to be dominant due to aggressiveness against subordinates in female social behavior (macaques model), high risks of suicidality, violence, and impulsive aggressiveness in 19–45 yo patients with schizophrenia; higher social aggressiveness in males (rat model); longer survival in aggressive leptin-deficient women with anorexia nervosa | |
rs200487063 | tgatcgggcc | \( \frac{\mathbf{g}}{a} \) | ctataagagg | \( \frac{\mathbf{4}}{2} \) | ↑ | 6 | 10−6 | (hypothetically) obesity-caused hypertension, and also, lower risk of aberrant maternal behavior, higher aggression against an unknown social stimulus, and locomotion activity on a high-fat diet (mice); higher chance to be dominant due to aggressiveness against subordinates in female social behavior (macaque model); lower risks of suicidality, violence, and impulsive aggressiveness in 19–45 yo schizophrenic patients; lower social aggressiveness in males (rat model) | ||
rs34104384 | ccgctataag | \( \frac{\mathbf{a}}{t} \) | ggggcgggca | \( \frac{\mathbf{4}}{3} \) | ↑ | 4 | 10−2 | |||