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Fig. 2 | BMC Genomics

Fig. 2

From: Candidate SNP markers of aggressiveness-related complications and comorbidities of genetic diseases are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters

Fig. 2

Cell culture verification of the candidate SNP marker rs201381696 in human cell lines transfected with the pGL 4.10 vector carrying a reporter LUC gene. Open bars, ancestral allele (wild type, WT); gray bars, minor allele; HCT116, a human colon adenocarcinoma cell line as an example of basal expression of the human LEP gene; MCF-7, a cell line of the human mammary gland epithelium carcinoma as an example of tissue-specific expression of this gene. The height of the gray bars and their error bars correspond to the mean estimates and their standard deviations calculated from at least three independent measurements. Asterisks indicate a statistically significant difference at the confidence level α < 0.05

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BMC Genomics

ISSN: 1471-2164

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